N-substituted N-benzyloxy-2-methyl-2-(4-halophenoxy)propionamides

ABSTRACT

This invention is concerned with N-substituted-N-benzyloxy-2methyl-2-(4-halophenoxy)propionamides of the following structure   wherein X is hydrogen, halo, (lower alkoxy) containing 1-7 carbon atoms, or phenyl; Y is halo; and R is hydrogen, (lower alkoxy)carbonyl, (lower alkanoyl) containing 1-7 carbon atoms or aroyl. These compounds are prepared by condensing 2-(4halophenoxy)-2-methylpropionyl chlorides with an appropriate benzyloxyamine to provide N-benzyloxy-2-methyl-2-(4halophenyl)propionamides in which R is hydrogen. The compounds wherein R is lower alkanoyl or aroyl are prepared by reacting Nbenzyloxy-2-methyl-2-(4-halophenyl)propionamide with a (lower alkanoyl) or aroyl chloride. These compounds are useful as antilipemic agents and also have antifungal utility.

United States Patent [191 Sprenger i 1 N-SUBSTITUTED N-BENZYLOXY-2-METHYL-2-(4- HALOPHENOXY )PROPIONAMIDES [75] Inventor: William K. Sprenger, Arlington 2] Appl No.: 495,359

[52] US. Cl. 260/559 B; 260/562 A [51] Int. Cl. C07C 103/32 [58] Field of Search 260/559 B, 562 A [56] References Cited UNITED STATES PATENTS 3 634,5l l l/l972 Howe et a]. i l r 260/559 B 1723,524 3/l973 Augstein et al, r. 260/559 A FOREIGN PATENTS OR APPLICATIONS 2,062,055 6/[97] Germany 260/562 A Primary ExaminerC. Davis Attorney, Agent, or Firm-John J, McDonnell [57] ABSTRACT This invention is concerned with N-substituted-N- wherein X is hydrogen, halo, (lower alkoxy) containing 1-7 carbon atoms, or phenyl; Y is halo; and R is hydrogen, (lower alkoxy)carbonyl, (lower alkanoyl) containing l-7 carbon atoms or aroyl. These compounds are prepared by condensing 2-(4- halophenoxy)-2-methylpropionyl chlorides with an appropriate benzyloxyamine to provide N-benzyloxy-Z- methyl-2-(4halophenyl)propionamides in which R is hydrogen. The compounds wherein R is lower alkanoyl or aroyl are prepared by reacting N-benzyloxy-Z- methyl-2-(4-halophenyl)propionamide with a (lower alkanoyl) or aroyl chloride. These compounds are useful as antilipemic agents and also have antifungal util ity.

9 Claims, No Drawings N-SUBSTITUTED N-BENZYLOXY-2-METHYL-2-(4-HALOPHENOX- Y )PROPIONAM] DES The present invention encompasses compounds of the formula wherein X is hydrogen, (lower alkoxy) containing l-7 carbon atoms, halo, or phenyl; Y is halo; and R is hydrogen, (lower alkoxy)carbonyl, (lower alkanoyl) containing l-7 carbon atoms or aroyl, preferably benzoyl.

Most preferred embodiments of this invention are those in which R is hydrogen, Y is chloro, and X is hydrogen, (lower alkoxy), halo or phenyl. Specifically, N-benzyloxy-2-methy-2-(4-chlorophenoxy)propionamide, N-4-chlorobenzyloxy-2-methy]-2-(4- chlorophenoxy)propionarnide, N-4- methoxybenzyloxy-2-methyl-2-(4-chlorophenoxy)propionamide, and N-4-phenylbenzyloxy-Z-methyl-2-(4- chlorophenoxy)propionamide are preferred.

The preferred embodiment of this invention when R is alkoxycarbonyl is N-ethoxycarbonyl-N-benzyloxy-2- methyl-2-(4-chlorophenoxy )propionamide.

The preferred embodiment of this invention when R is alkanoyl is N-acetyl-N-benzyloxy-2-methyl-2-(4- chlorophenoxy)propionamide.

The preferred embodiment of this invention when R is aroyl is N-benzoyl-N-benzyloxy-Z-methyl-2-( 4- chlorophenoxy)propionamide. Compounds of this invention are prepared as set out in Scheme 1.

Scheme l The hydrogen attached to the nitrogen may be replaced by reacting an alkanoyl halide such as acetyl chloride, an aroyl halide such as benzoyl chloride, or an alkoxycarbonyl halide such as ethyl chloroformate.

According to Scheme 2-(4-halophenoxy)-2- methylpropionyl chloride is reacted with benzyloxyamine to provide N-benzyloxy-2-(4-halophenoxy)-2- methylpropionamide.

Thus, 53 parts of 2-(4-chlorophenoxy)-2- methylpropionic acid (US. Pat. No. 3,625,950) is reacted with 60 parts of thionyl chloride to provide 2-( 4- chlorophenoxy)-2-methylpropionyl chloride. 8.2 Parts of this chloride is reacted with 5.6 parts of benzyloxyalamine hydrochloride in parts of LON sodium hydroxide solution to provide N-benzyloxy-2-methyl-2- (4-chlorophenoxy)propionamide. 2-(4- Methoxyphenoxy)-2-methylpropionoxamic acid is described in Japanese patent application no. 7039246 (Feb. 2, 1970) but the compounds of the present invention differ in structure in that they have a 2-(4- chlorophenoxy) instead of a 2-(4-methoxyphcnoxy) radical and a benzyloxy instead of hydroxy radical. N- mcthoxy 3-(4-chlorophenoxyJ-3-methylpropionamide is described in US. Pat. No. 3,625,950 (Dec. 7, 197] but the compounds of the present invention differ structurally in that they have an N-benzyloxy radical as well as other structural distinctions.

The compounds of this invention are useful as antifungal agents and they have hypolipenic activity. The anti-fungal activity of these compounds is exemplified by their activity against Triclzopliyron menragrophytes as determined by tests described in US. Pat. No. 3,682,95l, Column 3, lines 62-67 and Column 4, lines l-25.

The hypolipemic utility of the instant compounds is demonstrated by the following standardized test for their capacity to lower both serum cholesterol and serum triglycerides in rats. Charles River CD rats weighing 400-450 gm. apiece and maintained on tap water ad libitum are used in this test. To each of a group (Group I) of 8 such animals is administered in the powdered diet 0.2% of compound. The compound is incorporated by dissolving it in acetone or other volatile solvent and mixing the solution with the diet, whereupon the solvent is allowed to evaporate at room temperatures. The animals are fed the treated diet for 5 days. On the 6th day, serum samples are obtained and hypolipemic if the mean mg. serum cholesterol and 3 4 triglyceride values of Group I are significantly lower E 3 than for Group II. The level of significance in each in- EXAMPL stance is P 0.05 as determined by the Wilcoxon Rank Following the procedure set out in Example Sum method. parts of 2-(4-chlorophenoxy)-2-methylpropionyl chlo- The following examples are presented to further illusride is reacted with 6.3 partsof 4-methoxybenzyloxyatrate the present invention. They should not be conmine in 63 parts of LON sodium hydroxidesolution to strued as limiting it either in spirit or in scope. In these provide N-4-rnethoxybenzyloxy-2-m thyt2-( lexamples quantities are indicated in parts by weight unchlorophenoxy)propionar iide, melting at 78 79 This less parts by volume are specified, and temperatures Compound has the following structural formula I if T c o-i- --NO-CH C are indicated in degrees Centigrade (C. The relation- EXAMPLE 4 ship between parts by weight and parts by volume is the The following procedure Set out in Example I. 70

same as that existing between grams and milliliters. pans of 2 (4 ch|orophenoxy) 2 methy]propiony| chlo ride is reacted with 7.8 parts of 4-phenylbenzyloxya- EXAMPLE 1 mine in 63 parts of LON sodium hydroxide solution to 53 Parts of 2-(4-chlorophenoxy)-2-methylpropionic provide N-4-phenylbenzyloxy-2-methyl-2-(4- acid (US. Pat. No. 3,625,950) is reacted with 60 parts chlorophenoxy)propionamide, melting at 9l-93. This of thionyl chloride to provide 2-(4-chlorophenoxy)-2- compound has the following formula l Cl -OC-C-NO-CH,

methylpropionyl chloride. To a cold solution of 70 EXAMPLE 5 parts of LON sodium hydroxide solution containing 5.6 Following the procedure set out in Example 1, 7.l

parts of benzyloxyamine hydrochloride is added slowly parts of 2-( 4-chlorophenoxy )-2-rnethylpropionyl chlo- 8.2 parts of 2-(4-chlorophenoxy)-2-methylpropi0nyl ride is reacted with 6.4 parts of i 4- chloride. The reaction mixture is stirred for 2 hours and bromobenzyloxyamine solution in 63 parts of LON sothe solid which forms is separated and recrystallized dium hydroxide solution to provide N-4- from hexane to provide N-benzyloxy-2-methyl-2-(4- bromobenzyloxy-Z-methyl-2-(4-bromophenoxy)prochlorophenoxy)propionamide, melting at 59-60. pionamide. This compound is represented by the fol- This compound has the following structural formula lowing formula 1! Br oi E I 0 CH B CH3 EXAMPLE 6 To a solution of 6.4 parts of N-benzyloxy-2-methyl-2- c 0- -CN (4-chlorophenoxy )propionamide and 2.5 parts of tri- H 0-CH! ethylamine in 43.2 parts of methylene chloride at 0C. is added 2.0 parts of acetyl chloride. The reaction mixture is stirred for 30 minutes and allowed to warm to t EXAMPLE 2 room emperature and washed with ice water. The

methylene chloride layer is dried over anhydrous so- Following the procedure in Example 1, 7.0 parts of dium sulfate and the solvent is removed. The crude 2-(4-chlorophenoxy)-2-methylpropionyl chloride is reproduct is chromatographed on a silica gel column and acted with 6.4 parts of 4-chlorobenzyloxyamine in 63 6o eluted with benzene: 5% ethyl acetate solution. This parts of LON sodium hydroxide solution to provide N- procedure provided a fraction, which is N-acetyl-N- 4-chlorobenzyloxy- 2-methyl-2-( 4-chlorophenoxy )probenzyloxy-2-methyl-2-( 4-chlorophenoxy )propionapionamide, melting at 8 l. This compound has the mide, melting at 5862. This compound has the folfollowing formula lowing structural formula EXAMPLE 7 EXAMPLE 8 Following the procedures set out in Example 6, 6.4 parts of N-benzyloxy-2-methyl-2-(4-chlorophenoxy)- propionamide and 4.0 parts of pyridine are allowed to react with 32 parts of benzoyl chloride, thus providing N-benzoyl-N-benzyloxy-2-methyl-2-(4-chlorophenoxy)propionamide. This compound has the following structural formula EXAMPLE 9 Following the procedures set out in Example 6, 8.0 parts of N-benzyloxy-2-methyl-2-(4-chlorophenoxy)- propionamide and 2.5 parts of triethylamine in 63 parts of methylene chloride are reacted with 2.7 parts of 60 methyl chloroformate to provide N-methoxycarbonyl- N-benzyloxy-2-rnethyl-2-(4-chlorophenoxy)propionamidc. This compound has the following structural formula EXAMPLE 10 To a solution of 6.4 parts of N-benzyloxy-2-methyl-2- (4-chlorophenoxy)propionamide and 2.5 parts of triethylamine in 43.2 parts of methylene chloride at 0C. is added 2.0 parts of propionyl chloride. The reaction mikture is stirred for 30 minutes and allowed to warm to room temperature and washed with ice water. The methylene chloride layer is dried over anhydrous sodium sulfate and then the solvent is removed. The crude product is chromatographed on a silica gel column and eluted with benzene:5% ethyl acetate solution. This procedure provided a fraction, which is N- propionyl-N-benzyloxy-Z-methyl-2-(4-chlorophenoxy)propionamide. This compound has the following structural formula EXAMPLE 1 1 Following the procedure set out in Example 1, 7.0 parts of 2-( 4-chlorophenoxy )-2-methyl propionyl chloride is reacted with 6.3 parts of 4-ethoxybenzyloxyamine in 63 parts of LON sodium hydroxide solution to provide N-4-methoxybenzyloxy-2-methyl-2-( 4- chlorophenoxy)propionamide. This compound has the following structural fonnula OCQH,

What is claimed is: l. A compound of the formula wherein X is hydrogen, (lower alkoxy) containing 1-7 carbon atoms, halo, or phenyl', Y is halo; and R is hydrogen, (lower alkoxy )carbonyl, (lower alkanoyl) containing 1-7 carbon atoms or benzoyl.

2. As in claim 1, a compound of the formula wherein X is hydrogen, lower a'lkoxy containing l-7 carbon atoms, halo or phenyl and Y is halo.

3. As in claim I, the compound which is N- benzyloxy-2-methyl-2-(4-chlorophcnoxy)propionamidc.

4. As in claim 1, the compound which is N-4- chlorobcnzyloxy-2-methyl-2-( 4-chlorophenoxy )propionamide.

5. As in claim 1, the compound which is N-4- methoxybcnzyloxy-Z-methyl-2-( 4-chlorophenoxy )pro pionamide.

6. As in claim 1, the compound which is N-4- UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION PATENT NO. 1 3 ,911 O07 DATED Oct 7 1975 INVENI i William K. Sore-ruler It is certified that error appears in the above--rdentified patent and that sard Letters Patent are hereby corrected as shown below;

Abstract formula,

should read Column 2, line 18, "hypolipenic" should read hypolipemic Column 4, line 19, "The following" should read Following the Signed and Scaled this Arrest:

RUTH C. MASON C. MARSHALL DANN Arresting ()jfr'c'er ('mnmr'ssiuner ufPatents and Trademarks 

1. A COMPOUND OF THE FORMULA
 2. As in claim 1, a compound of the formula
 3. As in claim 1, the compound which is N-benzyloxy-2-methyl-2-(4-chlorophenoxy)propionamide.
 4. As in claim 1, the compound which is N-4-chlorobenzyloxy-2-methyl-2-(4-chlorophenoxy)propionamide.
 5. As in claim 1, the compound which is N-4-methoxybenzyloxy-2-methyl-2-(4-chlorophenoxy)propionamide.
 6. As in claim 1, the compound which is N-4-phenylbenzyloxy-2-methyl-2-(4-chlorophenoxy)propionamide.
 7. As in claim 1, the compound which is N-ethoxycarbonyl-N-benzyloxy-2-methyl-2-(4-chlorophenoxy)propionamide.
 8. As in claim 1, the compound which is N-acetyl-N-benzyloxy-2-methyl-2-(4-chlorophenoxy)propionamide.
 9. As in claim 1, the compound which is N-benzoyl-N-benzyloxy-2-methyl-2-(4-chlorophenoxy)propionamide. 